Analytical Data
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基因名
CaMKII delta/CAMK2D
- Application
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别名
(CaM kinase II subunit delta)(CaMK-II subunit delta)
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种属
Human
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表达系统
E. coli
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标签
C- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13557
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表达区间
2-499aa
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分子量
63.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CaMKII delta (CaMK2D) is a member of the Ca2+/calmodulin-dependent protein kinase II family, which plays a crucial role in various cellular processes, including synaptic plasticity, calcium signaling, and regulation of gene expression. Its involvement in heart physiology, particularly in cardiac hypertrophy and heart failure, has garnered significant interest in recent years. Research indicates that CaMKII delta is activated by elevated intracellular calcium levels, leading to its autophosphorylation and sustained activity, which can disrupt normal cardiac function when dysregulated. Moreover, aberrant CaMKII delta signaling has been linked to arrhythmias and other cardiovascular diseases. Given its pivotal role in these pathological conditions, the development of recombinant CaMKII delta proteins has become essential for understanding its biochemical and structural properties, as well as for exploring potential therapeutic targets. Producing and characterizing recombinant CaMKII delta allows researchers to investigate its interactions with various substrates and regulators, providing vital insights into the mechanistic pathways involved in cardiac signaling and disease progression. Thus, studying recombinant CaMKII delta not only enhances our comprehension of its physiological roles but also aids in identifying innovative strategies for treating CaMKII-related cardiac disorders. Through these investigations, we aim to pave the way for targeted therapies that could mitigate the detrimental effects of CaMKII delta dysregulation in cardiovascular health.
