Analytical Data
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基因名
BRSK1
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简介
The BRSK1 protein is a critical serine/threonine protein kinase that regulates cortical neuronal polarization and centrosome duplication. BRSK1 is phosphorylated and activated by STK11/LKB1, affecting neuronal polarization through MAPT/TAU phosphorylation (“Thr-529” and “Ser-579”) and WEE1 phosphorylation (“Ser-642”). BRSK1 Protein, Human (sf9, GST) is the recombinant human-derived BRSK1 protein, expressed by sf9 insect cells , with N-GST labeled tag.
- Application
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种属
Human
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表达系统
Baculovirus
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标签
N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TDC3
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表达区间
S2-P778
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BRSK1, or Brain/Skeletal Muscle Kinase 1, is a serine/threonine kinase that plays a significant role in various cellular processes, including cell growth, differentiation, and metabolism. It is part of the AMPK-related kinase family and is believed to be involved in the regulation of energy homeostasis and the response to cellular stress. Studies have indicated that BRSK1 may influence neuronal development and function, highlighting its potential implications in neurodegenerative diseases and conditions such as obesity and diabetes. The importance of BRSK1 has spurred interest in characterizing its structure and function, leading to the development of recombinant BRSK1 protein for research purposes. This recombinant protein serves as a crucial tool for studying its enzymatic activity, substrate specificity, and interaction with various cellular pathways. Additionally, understanding BRSK1's role in signaling cascades could provide insights into therapeutic targets for metabolic disorders and neurological conditions. As a result, ongoing research focused on the production and characterization of BRSK1 recombinant protein aims to elucidate its biological functions and therapeutic potential, ultimately contributing to the development of novel strategies for addressing related health issues.
