Analytical Data
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基因名
ITGA1
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简介
ITGA1 Protein, a cell surface receptor, plays a crucial role in cell adhesion, migration, and tissue development. Dysregulation of ITGA1 Protein has been linked to various diseases, including cancer and fibrosis. Targeting ITGA1 Protein may provide potential therapeutic interventions in these conditions by modulating cell adhesion, inhibiting tumor growth, and preventing tissue fibrosis. ITGA1 Protein, Human (HEK293, His) is the recombinant human-derived ITGA1 protein, expressed by HEK293, with C-His labeled tag.
- Application
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别名
Integrin alpha 1; ITGA1; CD49a; VLA-1
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种属
Human
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P56199-1
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表达区间
F29-P1141
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分子量
180 kDa, based on SDS-PAGE under non reducing conditions,.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The ITGA1 gene encodes the alpha-1 subunit of integrin, a crucial component of the extracellular matrix (ECM) that plays a significant role in cell adhesion, migration, and signaling. Integrins are heterodimeric proteins that mediate the interaction between cells and their surrounding environment, impacting various biological processes including tissue development, repair, and immune responses. Research on ITGA1 recombinant proteins has garnered attention due to their potential applications in understanding cellular interactions in health and disease. Alterations in integrin function, particularly ITGA1, have been implicated in various pathological conditions including cancer metastasis, fibrosis, and autoimmune disorders. By producing and studying ITGA1 recombinant proteins, researchers aim to elucidate the molecular mechanisms underlying integrin-mediated processes and to develop therapeutic interventions. Furthermore, these recombinant proteins serve as valuable tools for investigating integrin signaling pathways and for developing integrin-targeted therapies. The study of ITGA1 also holds promise in regenerative medicine, where modulating integrin interactions could enhance tissue engineering strategies. Overall, the ongoing research into ITGA1 recombinant proteins is vital for advancing our understanding of cellular dynamics and creating innovative treatment approaches for a range of diseases.
