Analytical Data
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Gene name
Semenogelin-1
- Application
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Alternative Names
Cancer/testis antigen 103 Semenogelin I Short name: SGI Cleaved into the following 3 chains: Alpha-inhibin-92 Alpha-inhibin-31 Seminal basic protein
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P04279
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Expression Region
24-402aa
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Molecular Weight
58.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Semenogelin-1 (SEMG1) is a significant protein component found in human semen, primarily involved in sperm function and fertility. As a major gel-forming protein in seminal plasma, SEMG1 plays a crucial role in the formation of the semen coagulum, which helps to stabilize sperm within the female reproductive tract, ultimately facilitating successful fertilization. Recent research has highlighted the significance of SEMG1 in regulating sperm motility and the subsequent release of sperm post-ejaculation. Its structure comprises multiple domains that contribute to its gel-forming properties and interaction with various seminal proteins. Furthermore, alterations in SEMG1 expression or functioning have been associated with male infertility, making it a potential biomarker for reproductive health assessments. As a result, the recombinant production of SEMG1 has garnered interest in both basic research and clinical applications. Researchers are exploring the potential of SEMG1 as a therapeutic target or a diagnostic tool to better understand male reproductive issues. Investigations into its molecular mechanisms, interactions with other proteins, and overall role in sperm biology are ongoing, highlighting its importance in reproductive medicine and fertility treatments. Understanding SEMG1's functions could pave the way for innovative strategies to enhance male fertility and address infertility disorders globally. Overall, SEMG1 presents a promising avenue for research in reproductive biology, providing insights that may lead to improved fertility treatments and a deeper comprehension of sperm dynamics.
