Analytical Data
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Gene name
DDR2
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简介
The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived DDR2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Biological Activity
Measured by its binding ability in a functional ELISA. Immobilized Collagen I at 10 µg/mL can bind Rhesus Macaque DDR2 with an apparent KD is 7.846 nM. Measured by its binding ability in a functional ELISA. Immobilized Collagen I at 10 µg/mL can bind Rhesus Macaque DDR2 with an apparent KD is 7.846 nM.
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Alternative Names
Discoidin domain-containing receptor 2; CD167b; Ddr2; Ntrkr3; Tkt; Tyro10
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Species
Rhesus Macaque
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
XP_001118219.1
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Expression Region
K22-R399
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AA Sequence
QVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSGALPTSPMTPTTYDPMLKIDDSNTR
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Protein Length
Partial
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Molecular Weight
50-70 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DDR2 (Discoidin Domain Receptor 2) is a receptor tyrosine kinase that plays a significant role in the regulation of cellular processes such as proliferation, differentiation, and extracellular matrix remodeling. It is primarily expressed in mesenchymal tissues and has garnered attention due to its involvement in various pathological conditions, including fibrosis, cancer metastasis, and cardiovascular diseases. DDR2 interacts with collagen and other components of the extracellular matrix, leading to activation of downstream signaling pathways that influence cellular behavior. Research on recombinant DDR2 proteins has expanded our understanding of its structural and biochemical properties, enabling the exploration of its functions in physiological and pathological contexts. Moreover, recombinant DDR2 has potential applications in drug development, where it can serve as a target for therapeutic intervention in diseases linked to dysregulated ECM interactions. The elucidation of DDR2's mechanisms and interactions through recombinant protein studies could pave the way for novel strategies to combat fibrotic diseases and improve cancer treatment outcomes. The ongoing investigation into the role of DDR2 in cell-matrix interactions underscores its importance in maintaining tissue homeostasis and its potential as a biomarker or therapeutic target in various diseases, making it a focal point of current biomedical research.
