Analytical Data
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基因名
HCK
- Application
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别名
JTK9; Hematopoietic cell kinase; p59-HCK/p60-HCK
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P08631
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表达区间
Gly2~Pro526
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分子量
63kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HCK (hemopoietic cell kinase) is a member of the Src family of tyrosine kinases that plays a crucial role in the regulation of various cellular processes, including cell proliferation, differentiation, and cytoskeletal organization. The study of HCK and its recombinant proteins has gained significant attention due to their potential implications in cancer research, immune response, and cell signaling pathways. Elevated levels of HCK have been observed in certain leukemias and lymphomas, suggesting its involvement in malignancies. Additionally, HCK is implicated in signaling pathways that govern immune cell function, making it a target for therapeutic intervention in autoimmune diseases and immunotherapy. Researchers are focusing on characterizing HCK's structure, function, and interactions with other proteins to gain insights into its biological roles and to develop pharmacological inhibitors that could serve as potential treatments. The production of recombinant HCK proteins allows for detailed studies of its enzymatic activity and the identification of key regulatory mechanisms, thus paving the way for novel therapeutic strategies aimed at modulating HCK activity in various diseases. As a result, understanding the biology of HCK through recombinant protein research is essential for elucidating its role in health and disease and could lead to innovative approaches in biomedical research and clinical practice.












