Analytical Data
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基因名
FGR
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简介
The FGR protein is a non-receptor tyrosine protein kinase that mediates immune regulation in various cell types. It transmits signals from receptors lacking kinase activity, affecting cytoskeletal remodeling, phagocytosis, adhesion, and migration. FGR Protein, Human (sf9, GST) is the recombinant human-derived FGR protein, expressed by sf9 insect cells , with N-GST labeled tag.
- Application
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别名
FGR; Tyrosine-protein kinase Fgr; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; Proto-oncogene c-Fgr; p55-Fgr; p58-Fgr; p58c-Fgr
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种属
Human
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表达系统
Baculovirus
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标签
N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P09769
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表达区间
G2-T529
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蛋白长度
Full Length of Mature Protein
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FGR, or Fms-related receptor tyrosine kinase 3, is a critical protein that belongs to the class of receptor tyrosine kinases (RTKs), which are essential for various cellular processes, including growth, differentiation, and survival. The study of FGR and its recombinant protein has gained significant attention in recent years due to its potential implications in cancer biology and therapeutic interventions. Abnormalities in FGR signaling pathways have been associated with several malignancies, making it a target of interest for cancer research. The recombinant form of FGR enables researchers to investigate its structural and functional characteristics in a controlled environment, facilitating studies on how it interacts with its ligands and downstream signaling molecules. Understanding FGR's role in these processes can provide insights into tumorigenesis and resistance mechanisms to existing therapies. Moreover, the production of recombinant FGR proteins offers opportunities for the development of novel inhibitors or antibodies that can block its activity, potentially leading to innovative treatment strategies for patients with FGR-related cancers. Overall, the exploration of FGR recombinant proteins is a crucial area of research that may lead to advancements in targeted cancer therapies and improved understanding of RTK signaling networks.
