Analytical Data
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Gene name
DYRK4
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简介
The DYRK4 protein may play a non-essential role in spermatogenesis, suggesting involvement in sperm cell development. Although specific functions and molecular mechanisms are unknown, its association with spermatogenesis suggests that it plays a role in complex pathways controlling male germ cell maturation. DYRK4 Protein, Human (sf9, His, FLAG) is the recombinant human-derived DYRK4 protein, expressed by sf9 insect cells , with N-Flag, N-8*His labeled tag.
- Application
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Alternative Names
DYRK4; Dual specificity tyrosine-phosphorylation-regulated kinase 4
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Species
Human
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Source
Baculovirus
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Tag
N-Flag;N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NR20
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Expression Region
M1-V520
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Protein Length
Full Length
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DYRK4 (Dual-specificity tyrosine phosphorylation-regulated kinase 4) is a member of the DYRK family of kinases, known for their roles in various cellular processes, including differentiation, proliferation, and stress responses. Research into DYRK4 has gained traction due to its implications in several diseases, particularly neurodegenerative conditions and cancers. It is uniquely characterized by its dual specificity for serine/threonine and tyrosine residues, which allows it to modulate multiple signaling pathways. Recent studies suggest that DYRK4 interacts with critical proteins involved in neuronal function and development, pointing to its potential as a therapeutic target. Furthermore, its dysregulation has been associated with aberrant cellular behaviors, highlighting the necessity for understanding its molecular mechanisms. Investigating DYRK4 recombinant proteins offers a valuable approach to elucidate its biological functions and regulatory roles within cells, paving the way for novel strategies in disease intervention. As research continues to unveil its complex interactions, DYRK4 stands out as a pivotal focus in the landscape of kinase biology and therapeutic development.
