Analytical Data
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Gene name
RBP1
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简介
RBP1 Protein, a cytoplasmic retinol-binding protein, functions in retinol uptake, storage, and retinoid homeostasis by accepting retinol from the transport protein STRA6. The interaction between RBP1 and STRA6 occurs specifically in the retinol-free apoprotein state. RBP1 Protein, Human is the recombinant human-derived RBP1 protein, expressed by E. coli , with tag free.
- Application
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Alternative Names
Retinol-binding protein 1; Cellular retinol-binding protein; CRBP; Cellular retinol-binding protein I; CRBP-I; RBP1; CRBP1
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P09455
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Expression Region
P2-Q135
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Protein Length
Partial
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Molecular Weight
14.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RBP1, or Retinoblastoma Binding Protein 1, is a crucial component in the regulation of gene expression and cellular processes, primarily known for its role in cell cycle control and tumor suppression. Research into RBP1 has gained significance due to its implication in various cancers, particularly retinoblastoma, where mutations in the RBP1 gene contribute to tumorigenesis. The recombinant expression of RBP1 provides valuable insights into its functional mechanisms, allowing scientists to dissect its interactions with other proteins, explore its role in cellular signaling pathways, and assess its potential as a therapeutic target. Advances in molecular biology techniques, particularly in recombinant DNA technology, have facilitated the production of RBP1 in heterologous systems, enabling the purification and characterization of the protein. This research not only enhances our understanding of RBP1’s biological functions but also opens avenues for developing novel cancer treatments that leverage its tumor-suppressive properties or correct its dysregulations in cancer cells. Consequently, the study of recombinant RBP1 holds promise for both basic research and clinical applications, furthering our knowledge of cancer biology and improving therapeutic strategies.
