Analytical Data
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基因名
YAP1
- Application
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别名
YAP; YAP2; YAP65; Transcriptional coactivator YAP1; Protein yorkie homolog; Yes-associated protein YAP65 homolog
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P46938
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表达区间
Met1~Leu488
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分子量
76kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
YAP1 (Yes-associated protein 1) is a key downstream effector of the Hippo signaling pathway, which plays a crucial role in regulating cell growth, proliferation, and organ size. Dysregulation of this pathway and overexpression of YAP1 have been implicated in various cancers, including liver, breast, and stomach cancers, making it a significant target for cancer research. Studies have shown that YAP1 promotes cell survival and proliferation by regulating gene expression and interacting with various transcription factors. As a result, the recombinant expression of YAP1 has gained attention for its potential in understanding the molecular mechanisms underlying tumorigenesis and for developing targeted therapies. Researchers aim to produce recombinant YAP1 proteins for structural and functional studies, to elucidate its role in oncogenesis, and to identify novel inhibitors that could mitigate its effects in cancerous cells. The study of YAP1 not only provides insights into cancer biology but also opens avenues for therapeutic interventions aimed at restoring normal Hippo signaling, ultimately contributing to the development of effective cancer treatment strategies.
