Analytical Data
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Gene name
GYS1
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简介
Glycogen synthase (GYS1) facilitates the transfer of a glycosyl residue from UDP-Glc to alpha-1,4-glucan, a vital step in glycogen synthesis. GYS1's enzymatic activity sequentially adds glucose residues to the growing glycogen chain, regulating cellular glycogen levels and contributing to energy storage and metabolism. GYS1 Protein, Human (His) is the recombinant human-derived GYS1 protein, expressed by E. coli, with C-His labeled tag.
- Application
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Alternative Names
GYS1; LGlycogen [starch] synthase; L muscle; L GYS; LGlycogen synthase 1
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Species
Human
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Source
E. coli
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P13807-1
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Expression Region
M1-N737
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Protein Length
Full Length of Isoform-1
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Molecular Weight
70-80 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GYS1, or glycogen synthase 1, is a critical enzyme involved in glycogen synthesis, playing a vital role in glucose metabolism and energy storage in mammals. Dysregulation of GYS1 has been linked to various metabolic disorders, including type 2 diabetes, obesity, and glycogen storage diseases, highlighting its importance in maintaining glucose homeostasis. The research into GYS1 recombinant proteins aims to elucidate the structure-function relationship of this enzyme, enabling a better understanding of its catalytic mechanisms and regulatory pathways. By expressing GYS1 in a recombinant system, scientists can produce large quantities of the protein for detailed functional assays and structural studies. Furthermore, the characterization of GYS1 recombinant proteins offers insights into potential therapeutic targets for metabolic diseases, facilitating the development of innovative treatments. Overall, the study of GYS1 recombinant protein not only enhances our comprehension of glycogen metabolism but also contributes to the broader field of metabolic research, paving the way for advancements in disease management and prevention.
