Analytical Data
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Gene name
Integrin alpha IV beta 1
- Application
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Alternative Names
Integrin alpha 4 beta 1 ; ITGA4&ITGB1
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Species
Human
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P13612-1 (Y34-T977)& P05556-1
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Expression Region
P13612-1 (Y34-T977)& P05556-1 (Q21-D728)
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Molecular Weight
60-75 kDa (ITGA4), 110-140 kDa (ITGA1), based on SDS-PAGE under non reducing (N) conditions,.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Integrin alpha IV beta 1 is a crucial cell surface receptor composed of two subunits, alpha IV and beta 1, playing a significant role in cell adhesion, migration, and signaling processes. This integrin is primarily expressed in various cell types, including endothelial and vascular smooth muscle cells, and is involved in important physiological functions such as angiogenesis, tissue repair, and immune response. Dysregulation of integrin alpha IV beta 1 has been implicated in several pathological conditions, including cancer metastasis and inflammatory diseases. Therefore, the study of recombinant integrin alpha IV beta 1 proteins has gained attention in the field of biomedical research, as they serve as valuable tools for elucidating the molecular mechanisms underlying integrin functions and interactions. Additionally, these recombinant proteins can be utilized in developing therapeutic strategies targeting integrin-mediated pathways. By investigating the structure, binding affinities, and downstream signaling pathways of integrin alpha IV beta 1, researchers aim to enhance our understanding of its role in both physiological and pathological contexts, paving the way for novel interventions in diseases where integrin function is compromised. This ongoing research is crucial for translating basic science into clinical applications, ultimately aiming to improve patient outcomes through targeted therapeutic approaches.
