Analytical Data
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基因名
Integrin alpha IV beta 1
- Application
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别名
Integrin alpha 4 beta 1 ; ITGA4&ITGB1
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种属
Human
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P13612-1 (Y34-T977)& P05556-1
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表达区间
P13612-1 (Y34-T977)& P05556-1 (Q21-D728)
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分子量
60-75 kDa (ITGA4), 110-140 kDa (ITGA1), based on SDS-PAGE under non reducing (N) conditions,.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Integrin alpha IV beta 1 is a crucial cell surface receptor composed of two subunits, alpha IV and beta 1, playing a significant role in cell adhesion, migration, and signaling processes. This integrin is primarily expressed in various cell types, including endothelial and vascular smooth muscle cells, and is involved in important physiological functions such as angiogenesis, tissue repair, and immune response. Dysregulation of integrin alpha IV beta 1 has been implicated in several pathological conditions, including cancer metastasis and inflammatory diseases. Therefore, the study of recombinant integrin alpha IV beta 1 proteins has gained attention in the field of biomedical research, as they serve as valuable tools for elucidating the molecular mechanisms underlying integrin functions and interactions. Additionally, these recombinant proteins can be utilized in developing therapeutic strategies targeting integrin-mediated pathways. By investigating the structure, binding affinities, and downstream signaling pathways of integrin alpha IV beta 1, researchers aim to enhance our understanding of its role in both physiological and pathological contexts, paving the way for novel interventions in diseases where integrin function is compromised. This ongoing research is crucial for translating basic science into clinical applications, ultimately aiming to improve patient outcomes through targeted therapeutic approaches.
