Analytical Data
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基因名
EIF4EBP1
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简介
EIF4EBP1 is a translation initiation repressor protein that complexly regulates EIF4E activity. In the hypophosphorylated state, EIF4EBP1 competes with EIF4G1/EIF4G3 to inhibit translation by binding to EIF4E. EIF4EBP1 Protein, Human (His) is the recombinant human-derived EIF4EBP1 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13541
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表达区间
M1-I118
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蛋白长度
Full Length
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分子量
17.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EIF4EBP1, also known as eukaryotic translation initiation factor 4E-binding protein 1, is a pivotal regulator of protein synthesis, influencing cellular growth, proliferation, and survival. It functions primarily by binding to the eukaryotic translation initiation factor 4E (eIF4E), inhibiting its interaction with the mRNA cap structure and thereby controlling the initiation of translation. Dysregulation of EIF4EBP1 has been implicated in various diseases, including cancer, where its expression and activity can significantly affect tumorigenesis and response to treatment. Therefore, researchers have focused on elucidating the structural and functional properties of EIF4EBP1, particularly in understanding how its phosphorylation state and protein interactions dictate its role in translation regulation under different cellular conditions. Recombinant EIF4EBP1 protein studies enable detailed investigation of its biological functions, mechanisms of action, and potential as a therapeutic target. By producing and characterizing recombinant forms of EIF4EBP1, scientists aim to better understand its regulatory network, interactions with other translation factors, and its role in disease progression. This research ultimately contributes to the broader field of translational control and offers insights into developing novel strategies for treating diseases associated with impaired protein synthesis.
