Analytical Data
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基因名
Histatin-3/HTN3
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简介
The Histatin-3/HTN3 protein is a key salivary component and a major precursor in the formation of the enamel film on the tooth surface. In addition to its structural role, histatin-3 also exhibits antibacterial and antifungal activity, particularly through its His3-(20-43)-peptide (histatin-5). Histatin-3/HTN3 Protein, Human is the recombinant human-derived Histatin-3/HTN3 protein, expressed by E. coli , with tag free.
- Application
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别名
rHuHistatin-3/HTN3; Histatin-3; Basic histidine-rich protein; Histidine-rich protein 3; PB; HTN3.
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P15516
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表达区间
D20-N51
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蛋白长度
Full Length of Mature Protein
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分子量
10-12 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Histatin-3 (HTN3) is a significant salivary protein that plays a crucial role in oral health, particularly in antimicrobial activity and wound healing. It is part of the histatin family, which is known for its ability to inhibit the growth of various pathogens, including bacteria and fungi, particularly Candida species. The increasing prevalence of drug-resistant microbial infections highlights the necessity for novel antimicrobial agents, making HTN3 an attractive candidate for therapeutic applications. Recent studies have demonstrated its potential not only in combating oral infections but also in influencing the inflammatory response during wound healing. Furthermore, recombinant technologies have enabled the production of HTN3 in sufficient quantities for research, allowing for detailed investigations into its structure-function relationships. This has paved the way for exploring its mechanism of action at the molecular level, including its interactions with microbial membranes and its influence on host immune responses. The growing interest in HTN3 is also driven by its potential use in developing new treatments for conditions where microbial resistance is a concern. Overall, the study of Histatin-3 represents a promising avenue for advancing our understanding of antimicrobial peptides and their potential applications in clinical settings.
