Analytical Data
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基因名
NPTX2
- Application
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别名
NPTX2; Neuronal pentraxin-2; NP2; Neuronal pentraxin II (NP-II)
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种属
Human
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P47972
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表达区间
G16-L431
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氨基酸序列
GAQDSPAPGSRFVCTALPPEAVHAGCPLPAMPMQGGAQSPEEELRAAVLQLRETVVQQKETLGAQREAIRELTGKLARCEGLAGGKARGAGATGKDTMGDLPRDPGHVVEQLSRSLQTLKDRLESLEHQLRANVSNAGLPGDFREVLQQRLGELERQLLRKVAELEDEKSLLHNETSAHRQKTESTLNALLQRVTELERGNSAFKSPDAFKVSLPLRTNYLYGKIKKTLPELYAFTICLWLRSSASPGIGTPFSYAVPGQANEIVLIEWGNNPIELLINDKVAQLPLFVSDGKWHHICVTWTTRDGMWEAFQDGEKLGTGENLAPWHPIKPGGVLILGQEQDTVGGRFDATQAFVGELSQFNIWDRVLRAQEIVNIANCSTNMPGNIIPWVDNNVDVFGGASKWPVETCEERLLDL
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蛋白长度
Full Length of Mature Protein
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分子量
50-63 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Neurogranin is a neuronal protein primarily expressed in the brain, known for its role in synaptic plasticity and cognition. Its expression is correlated with learning and memory processes, making it a crucial focus in neuroscience research. As a modulator of calcium signaling, neurogranin binds to calcium ions, which influences protein kinase activity and subsequent neuronal signaling pathways. Research has indicated that alterations in neurogranin levels may be associated with various neurodegenerative diseases, particularly Alzheimer's disease, where its concentration is significantly altered. The study of recombinant neurogranin protein involves the cloning and expression of its gene to produce the protein in vitro, facilitating a deeper understanding of its structure, function, and potential therapeutic applications. By utilizing recombinant technology, scientists aim to investigate the specific mechanisms by which neurogranin contributes to synaptic function and plasticity, as well as its role in disease progression. This research not only enhances our understanding of fundamental neurobiology but also opens avenues for developing targeted interventions in neurodegenerative conditions, potentially leading to novel biomarkers or treatment strategies.
