Analytical Data
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基因名
GADD45B
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简介
GADD45B Protein, a pivotal mediator, regulates growth and apoptosis by activating the MTK1/MEKK4 MAPKKK signaling pathway. Interacting with GADD45GIP1, it forms a complex that modulates cellular responses under stress. Its central role in growth and apoptosis underscores its significance in orchestrating cellular processes, positioning GADD45B as a key player in the intricate network of signaling pathways governing cell fate decisions. GADD45B Protein, Human (His) is the recombinant human-derived GADD45B protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75293
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表达区间
M1-R160
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蛋白长度
Full Length
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分子量
19 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GADD45B (Growth Arrest and DNA Damage-inducible protein 45 beta) is a member of the GADD45 family, which is known to be involved in cellular stress responses, DNA repair, and apoptosis. Research on GADD45B has gained attention due to its potential role in cancer biology and other diseases, as well as its regulatory influence on cell proliferation and survival. The expression of GADD45B is often upregulated in response to various stressors, including oxidative stress, UV irradiation, and DNA damage, indicating its involvement in the cellular defense mechanism. Additionally, studies have suggested that GADD45B may act as a tumor suppressor, with its downregulation contributing to oncogenesis in several cancer types. Understanding the function and regulatory mechanisms of GADD45B at a molecular level is crucial for elucidating its role in disease pathogenesis and for exploring its potential as a therapeutic target. The generation of recombinant GADD45B protein has facilitated in-depth investigations into its biochemical properties and interactions with other cellular molecules, paving the way for novel therapeutic strategies aimed at modulating its activity to combat cancer and other stress-related diseases. The ongoing research efforts to characterize GADD45B's functions and the pathways it influences are promising, potentially leading to significant advancements in targeted treatments and improved understanding of tumor biology.
