Analytical Data
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基因名
FGFRL1
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简介
The FGFRL1 protein negatively affects cell proliferation, revealing its role as a potential regulator during cell growth. In addition, it interacts with FGF2, showing significant but low affinity for this fibroblast growth factor. FGFRL1 Protein, Human (HEK293, His) is the recombinant human-derived FGFRL1 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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别名
Fibroblast growth factor receptor-like 1; FGFR-5; FGFRL1; FGFR5; FHFR
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N441
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表达区间
A25-P378
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氨基酸序列
ARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWP
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蛋白长度
Extracellular Domain
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分子量
65 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FGFRL1 (Fibroblast Growth Factor Receptor-Like 1) is a member of the fibroblast growth factor receptor family and plays a critical role in various biological processes, including cell proliferation, differentiation, and migration. Unlike classical FGFRs, FGFRL1 lacks a functional kinase domain, suggesting that its mechanisms of action may differ from those of traditional receptors. Recent studies have highlighted the importance of FGFRL1 in modulating cellular responses to growth factors, as well as its potential involvement in tumorigenesis and tissue regeneration. Given that FGFRL1 has been implicated in several pathophysiological conditions, including cancer and cardiovascular diseases, researchers have focused on developing recombinant FGFRL1 proteins to better understand its biological functions and therapeutic potential. Recombinant FGFRL1 proteins allow scientists to study the receptor's structure-function relationships, investigate its interactions with ligands, and explore its signaling pathways. Moreover, these studies may pave the way for novel therapeutic strategies targeting FGFRL1, offering potential interventions for diseases linked to dysregulated FGF signaling. As the biotech community continues to unravel the complexities surrounding FGFRL1, the development of these recombinant proteins is essential for elucidating the receptor's role in health and disease.
