Analytical Data
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基因名
Fetuin A/AHSG
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简介
Fetuin A/AHSG Protein is a heterodimeric plasma glycoprotein containing an A-chain of 282 amino acids and a B-chain of 27 amino acid residues linked by a single inter-disulfide bond. Fetuin A is a plasma carrier protein that helps to transport and make a wide range of substances available in the bloodstream. Fetuin A is a hepatokine which has the capacity to prevent vascular calcification. Fetuin A is a multifunctional protein that plays important roles in diabetes, kidney disease, and cancer, as well as in inhibition of ectopic calcification[1][2][3]. Fetuin A/AHSG Protein, Macaca mulatta (HEK293, His) is the recombinant Fetuin A/AHSG protein, expressed by HEK293 , with C-10*His labeled tag.
- Application
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别名
rMaAlpha-2-HS-glycoprotein/Fetuin A; Fetuin A; AHSG
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种属
Others
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表达系统
HEK293
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标签
C-10*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
A0A2K6AQI2
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表达区间
A19-V367
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氨基酸序列
APHGPGLIYRQPNCDDPETEEAALVAVDYINQNLPWGYKHTLNQIDEVKVWPQQPFGEMFEIEIDTLETTCHVLDPTPVAGCRVRQLKEHAVEGDCDFQLLKVNGKFSVEYAKCDSSPDSAEDVRKVCRDCPLLAPLNDTRVVHAAEAAVTAFNAQNNGSNFQLEEISRAQLVPLPPSTYVEFTISGTDCVAKEATEAANCNLLAKKQYGFCKATLNEKLGGEEVAVTCTVFQTQPATSQPQPEGANEAVPTPVVDADAPASYPVGASGPLPTGSPIYAHVLAAAPPVVPIHSSHYDLRHLFMGVVSLRSPSGEALHPRKTRSVVQPSVGAAAGPVVPPCPGRVRHFKV
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蛋白长度
Full Length of Mature Protein
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分子量
50.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Fetuin A, also known as alpha-₂-HS-glycoprotein (AHSG), is a glycoprotein predominantly produced by the liver and plays a critical role in several biological processes, including mineral metabolism, insulin signaling, and regulation of inflammation. Recent research has highlighted its potential implications in various diseases, including cardiovascular disorders, diabetes, and obesity. The interest in recombinant Fetuin A arises from the need for understanding its biological functions in detail and exploring its therapeutic potential. By producing recombinant forms of this protein, scientists aim to investigate its mechanisms of action, elucidate its interactions with cellular receptors, and evaluate its effects on metabolic pathways. Furthermore, the development of recombinant Fetuin A could serve as a valuable tool for drug discovery and the development of therapeutic strategies aimed at mitigating diseases related to its dysregulation. Consequently, the production and characterization of recombinant Fetuin A/AHSG have become a significant focus in biomedical research, paving the way for potential applications in clinical settings and enhancing our understanding of its role in health and disease.
