Analytical Data
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基因名
TGF alpha/TGFA
- Application
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别名
ETGF; TGF-A; Protransforming Growth Factor alpha; EGF-Like TGF
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种属
Rabbit
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 97% as determined by SDS-PAGE.
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蛋白编号
P98138
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表达区间
Glu24~Ala98
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蛋白长度
Partial
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分子量
15kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Transforming Growth Factor Alpha (TGF-alpha), also known as TGFA, is a key member of the EGF (Epidermal Growth Factor) family of peptides, which plays a critical role in cellular proliferation, differentiation, and survival. This protein is predominantly involved in the regulation of epithelial development and tissue repair, making it crucial in various physiological and pathological processes, including wound healing, organ regeneration, and tumorigenesis. Research has shown that TGF-alpha is overexpressed in several types of cancers, contributing to increased cell growth and metastasis. Consequently, understanding the molecular mechanisms underlying TGF-alpha signaling can provide valuable insights for therapeutic interventions in cancer and other diseases. The development of recombinant TGF-alpha proteins has enabled scientists to study its biological functions in greater detail, allowing for the exploration of its potential as a therapeutic target. By utilizing advanced recombinant DNA technology, researchers can produce large quantities of functional TGF-alpha, facilitating studies on its interactions with specific receptors and downstream signaling pathways. Furthermore, recombinant TGF-alpha can be employed in various in vitro and in vivo models to elucidate its effects on cellular behaviors and to test novel cancer treatments. Overall, the research surrounding TGF-alpha/TGFA recombinant proteins is not only essential for enhancing our understanding of growth factor biology but also holds promise for innovative therapeutic strategies in oncology and regenerative medicine.
