Analytical Data
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基因名
Lgr4/GPR48
- Application
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别名
Leucine-rich repeat-containing G-protein coupled receptor 4(G-protein coupled receptor 48)
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种属
Human
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表达系统
Baculovirus
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标签
C- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BXB1
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表达区间
25-544aa
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分子量
62.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Lgr4, also known as GPR48, is a member of the leucine-rich repeat-containing G protein-coupled receptor (GPCR) family, which plays a critical role in various biological processes, including cell proliferation, differentiation, and tissue homeostasis. As a receptor for the Wnt signaling pathway, Lgr4 is implicated in the regulation of stem cell maintenance and has been linked to processes such as tissue regeneration and development. Research has shown that Lgr4 modulates key developmental signaling pathways and influences several cellular functions, making it a significant target for therapeutic exploration in regenerative medicine and cancer treatment. The recombinant protein of Lgr4/GPR48 has been engineered for detailed studies to elucidate its structure-function relationship and interaction with ligands, offering insights into its physiological roles and potential as a drug target. Understanding the molecular mechanisms by which Lgr4 exerts its effects can facilitate the development of novel strategies to manipulate cellular pathways in various diseases, thereby advancing the field of targeted therapy. Additionally, the study of Lgr4/GPR48 may contribute to the understanding of GPCR signaling in broader biological contexts, underlining its importance in both academic and clinical research.
