Analytical Data
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基因名
PLVAP
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简介
The PLVAP protein is an endothelial cell-specific membrane protein that plays a key role in the complex structure of endothelial fenestrae by participating in the formation of septa that bridge these fenestrae. Furthermore, it plays a crucial role in the development of stomata within caveolae and transendothelial channels. PLVAP Protein, Human (HEK293, His) is the recombinant human-derived PLVAP protein, expressed by HEK293 , with N-His labeled tag.
- Application
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别名
Plasmalemma vesicle-associated protein; FELS; PV1
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种属
Human
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表达系统
HEK293
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标签
N-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BX97
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表达区间
Y49-G442
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蛋白长度
Extracellular Domain
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分子量
50-70 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PLVAP (Plasmalemma Vesicle Associated Protein) is a key protein involved in the regulation of endothelial permeability and is primarily expressed in the blood vessels, particularly in the microvascular endothelium. Its expression is crucial for maintaining the integrity of the blood-brain barrier and other tissue-specific barriers. Research into PLVAP has gained momentum due to its potential implications in various pathophysiological conditions, such as inflammation, tumor metastasis, and vascular diseases. Studies have shown that PLVAP plays a significant role in transcytosis and vesicular trafficking processes, impacting the movement of molecules and cells across endothelial barriers. The recombinant production of PLVAP has become an important focus to better understand its structural and functional properties. By employing advanced recombinant DNA technology, researchers can generate high-purity PLVAP proteins, facilitating in-depth studies on their biochemical characteristics and interactions with other cellular components. Furthermore, investigating PLVAP in a recombinant form allows for the development of targeted therapeutic strategies aimed at modulating vascular permeability in diseases associated with dysregulated endothelial function. Overall, the study of recombinant PLVAP not only enhances our understanding of its role in vascular biology but also opens avenues for novel therapeutic interventions in diseases characterized by altered endothelial permeability.
