Analytical Data
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Gene name
CAMKIV/CAMK4
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简介
CAMKIV/CAMK4 protein, a calcium/calmodulin-dependent kinase, regulates transcription activators (CREB1, MEF2D, JUN, and RORA) in immune response, inflammation, and memory consolidation. It controls thymocyte selection, TCR signaling, osteoclast and dendritic cell survival, and memory consolidation in hippocampal neurons. It activates MAP kinases, ELK1, ATF2, and potentially participates in spermatogenesis. CAMKIV/CAMK4 Protein, Mouse (sf9) is the recombinant mouse-derived CAMKIV/CAMK4 protein, expressed by Sf9 insect cells, with tag free.
- Application
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Alternative Names
Calcium/calmodulin-dependent protein kinase type IV; CaMK IV; CAMK4; CAMK; CAMK-GR
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Species
Mouse
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Source
Baculovirus
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P08414
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Expression Region
P08414 (N-G&P, M1-Y469)
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Protein Length
Full Length
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Molecular Weight
55 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CAMKIV, also known as Calcium/Calmodulin-dependent Protein Kinase IV (CAMK4), is a serine/threonine kinase that plays a critical role in various cellular processes, including gene expression, neuronal signaling, and immune responses. Its activation is primarily regulated by calcium ions and calmodulin, making it a vital component in calcium signaling pathways. Research on CAMKIV/CAMK4 has gained momentum due to its association with several physiological processes and pathological conditions, including cardiac hypertrophy, neurodegenerative diseases, and cancer. The study of recombinant CAMKIV/CAMK4 proteins has been essential for understanding their structure-function relationships and for identifying potential therapeutic targets. By producing and characterizing these recombinant proteins, researchers aim to elucidate the mechanisms of CAMKIV activation and its downstream signaling pathways. Furthermore, insights gained from these studies could lead to the development of novel therapeutic strategies to modulate CAMKIV activity in various diseases, highlighting the importance of understanding this kinase at a molecular level for both basic and applied biomedical research.
