Analytical Data
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基因名
MMP-19
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简介
MMP-19 proteins act as endopeptidases that degrade multiple components of the extracellular matrix, including aggrecan and cartilage oligomeric matrix protein (comp), during critical developmental processes, hemostasis, and pathological conditions such as arthritis. ) plays a key role. In addition to participating in matrix remodeling, MMP-19 may also contribute to neovascularization, or angiogenesis. MMP-19 Protein, Human (solution) is the recombinant human-derived MMP-19 protein, expressed by E. coli , with tag free.
- Application
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别名
Matrix metalloproteinase-19; MMP-19; MMP-18; RASI
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99542-1
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表达区间
L101-G256
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蛋白长度
Partial
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分子量
18 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Matrix metalloproteinase-19 (MMP-19) is a member of the matrix metalloproteinase (MMP) family, enzymes that play a crucial role in the remodeling of the extracellular matrix. MMP-19 is unique among MMPs, as it can be expressed in various tissues and is involved in several physiological and pathological processes, including embryogenesis, wound healing, and tissue repair. Recent studies have indicated that MMP-19 may have a significant role in inflammatory diseases and cancer progression, making it a potential target for therapeutic interventions. The recombinant expression of MMP-19 has gained attention in research due to its implications in understanding these diseases and developing novel treatments. By producing recombinant MMP-19, researchers can investigate its enzymatic properties, such as substrate specificity and regulation, as well as its interactions with other proteins within the extracellular matrix. This can provide valuable insights into its biological functions and the mechanisms underlying various diseases. Furthermore, MMP-19’s involvement in modulating cell migration and invasion emphasizes its relevance in cancer biology, as it may contribute to tumor metastasis. Given these factors, the study of recombinant MMP-19 not only enhances our knowledge of its biological roles but also opens avenues for the development of MMP-targeted therapies, potentially improving outcomes in conditions associated with aberrant matrix remodeling and inflammation.
