Analytical Data
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基因名
LAMTOR1
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简介
The LAMTOR1 protein is an important component of the Ragulator complex and plays dual roles in amino acid sensing and mTORC1 activation. It acts as a guanine nucleotide exchange factor (GEF) for Rag GTPases and mediates their recruitment to the lysosomal membrane. LAMTOR1 Protein, Human (His) is the recombinant human-derived LAMTOR1 protein, expressed by E. coli , with N-His labeled tag.
- Application
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6IAA8
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表达区间
G2-P161
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蛋白长度
Full Length of Mature Protein
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分子量
It migrates as 24 kDa in SDS-PAGE may be due to relative charge.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LAMTOR1, also known as late endosomal/lysosomal adaptor, MAPK and mTOR activator 1, is a crucial protein that plays a significant role in the regulation of mTOR signaling pathway, which is essential for cell growth, proliferation, and metabolism. Research has highlighted LAMTOR1's function as an adaptor protein that facilitates the assembly of the mTORC1 complex at lysosomal membranes, thereby influencing nutrient sensing and autophagy processes. The dysregulation of mTOR signaling has been implicated in various diseases, including cancer, metabolic disorders, and neurodegenerative conditions, making LAMTOR1 a potential therapeutic target. Studies have shown that LAMTOR1 interacts with several key proteins involved in cellular signaling, including Rag GTPases, which are essential for mTORC1 activation in response to amino acids and other growth factors. The recombinant production of LAMTOR1 protein enables detailed studies of its structure and function, providing insights into its role in cellular signaling pathways. Understanding the molecular mechanisms underpinning LAMTOR1's function could lead to novel therapeutic strategies for diseases linked to mTOR dysregulation. Moreover, characterizing LAMTOR1 as a recombinant protein allows researchers to elucidate its interactions with other signaling components, paving the way for innovative drug design and therapeutic interventions aimed at restoring normal signaling pathways in disease contexts. Thus, the study of LAMTOR1 and its recombinant protein forms represents a significant advance in our understanding of cellular signaling and its implications for human health.
