Analytical Data
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Gene name
CHMP6
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简介
The CHMP6 protein is a core component of ESCRT-III and plays a key role in the formation of multivesicular bodies (MVBs) for endosomal cargo protein sorting. MVB is essential for the degradation of membrane proteins transported to lysosomes. CHMP6 Protein, Human (His, Strep) is the recombinant human-derived CHMP6 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.
- Application
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Alternative Names
CHMP6; Charged multivesicular body protein 6; Chromatin-modifying protein 6; Vacuolar protein sorting-associated protein 20; Vps20; hVps20
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Species
Human
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Source
E. coli
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Tag
N-StrepⅡ;N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96FZ7
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Expression Region
M1-S201
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Protein Length
Full Length
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CHMP6 (charged multivesicular body protein 6) is a crucial component of the endosomal sorting complexes required for transport (ESCRT) machinery, which plays a significant role in cellular processes such as multivesicular body formation, endocytosis, and the degradation of membrane proteins. Research into CHMP6 has gained momentum due to its involvement in various physiological and pathological processes, including viral budding, cell division, and the regulation of signaling pathways. It is particularly of interest in the context of diseases, such as cancers and neurodegenerative disorders, where the dysregulation of endosomal trafficking can lead to aberrant cellular behavior. The recombinant protein form of CHMP6 is being studied for its potential to elucidate the molecular mechanisms underlying these processes. By producing CHMP6 as a recombinant protein, researchers can explore its functional properties, interactions with other ESCRT components, and its role in cellular dynamics. This is critical for identifying novel therapeutic targets and developing strategies for intervention in diseases where CHMP6 and its associated pathways are implicated. Overall, the study of recombinant CHMP6 promises to enhance our understanding of cellular transport mechanisms and their implications in health and disease.
