Analytical Data
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基因名
Histone H1
- Application
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别名
Histone H1' Histone H1(0)
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P07305
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表达区间
1-194aa
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分子量
47.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Histone H1 is a pivotal component of the chromatin structure, playing a crucial role in the packaging of DNA into higher-order structures and regulating gene expression. As a member of the linker histone family, H1 binds to the nucleosome, facilitating the formation of chromatin fibers and contributing to the overall stability and compaction of the chromatin. Research on recombinant histone H1 has gained momentum due to its potential applications in understanding chromatin dynamics, epigenetic regulation, and cellular processes such as transcription and replication. The ability to produce recombinant H1 allows for the investigation of its specific functions, interactions with DNA, and influence on chromatin architecture in a controlled setting. Furthermore, studying H1 in recombinant forms aids in elucidating the mechanisms by which post-translational modifications of histones contribute to the regulation of chromatin states and gene expression. Given the critical role of histone H1 in cellular processes and its implications in disease, including cancer and developmental disorders, ongoing research is focused on manipulating H1 expression and studying its effects on cellular function and chromatin remodeling. Understanding the complexities of histone H1 dynamics and interactions at the molecular level could provide insights into targeted therapeutic strategies for various diseases linked to chromatin dysregulation.
