Analytical Data
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Gene name
SLC16A2
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简介
The SLC16A2 protein is a specific thyroid hormone transmembrane transporter that promotes bidirectional movement of thyroid hormone across cell membranes independent of pH or Na(+) gradients. SLC16A2 has a significant preference for substrates such as T3 and T4 and is a key mediator of thyroid hormone transport. SLC16A2 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC16A2 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
- Application
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Alternative Names
SLC16A2; Monocarboxylate transporter 8; MCT 8; Monocarboxylate transporter 7; MCT 7; Solute carrier family 16 member 2; X-linked PEST-containing transporter
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Species
Human
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Source
Baculovirus
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Tag
N-MBP;C-Flag;N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P36021
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Expression Region
A2-I539
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Protein Length
Full Length of Mature Protein
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC16A2, also known as the monocarboxylate transporter 8 (MCT8), is a crucial protein involved in the intracellular transport of thyroid hormones, particularly thyroxine (T4) and triiodothyronine (T3). Mutations in the SLC16A2 gene are linked to X-linked intellectual disability and severe disturbances in thyroid hormone levels, emphasizing its vital role in brain development and function. As thyroid hormones are essential for various neurological processes, understanding the mechanisms of SLC16A2 transport activity has significant implications for both basic research and clinical applications, particularly in the context of thyroid disorders. The recombinant SLC16A2 protein serves as a valuable tool for studying the functional properties of this transporter, enabling researchers to investigate its substrate specificity, transport kinetics, and regulatory pathways. By producing and analyzing SLC16A2 in a controlled laboratory setting, scientists can better understand how alterations in transporter function may contribute to disease phenotypes and pave the way for potential therapeutic strategies. This research is further enhanced by advanced techniques such as molecular modeling, site-directed mutagenesis, and electrophysiological assays, which collectively aim to elucidate the structure-function relationship of SLC16A2. Understanding its biological mechanisms can help to inform the development of targeted treatments for conditions associated with SLC16A2 mutations, ultimately improving healthcare outcomes for affected individuals.
