Analytical Data
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基因名
MMP-8
- Application
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别名
(Matrix metalloproteinase-8)(MMP-8)(PMNL collagenase)(PMNL-CL)
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种属
Human
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P22894
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表达区间
101-467aa
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分子量
49.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Matrix metalloproteinase-8 (MMP-8), also known as collagenase-2, is a member of the matrix metalloproteinase family, which plays a crucial role in extracellular matrix remodeling and tissue homeostasis. This enzyme is predominantly expressed in neutrophils and is involved in the degradation of type I and type III collagen, which are essential for maintaining the structural integrity of connective tissues. Dysregulation of MMP-8 activity has been implicated in various pathological conditions, including inflammatory diseases, cancer metastasis, and periodontal diseases. Its dual roles in tissue remodeling—facilitating normal physiological processes as well as contributing to disease progression—make it a significant target for therapeutic interventions. In recent years, significant research efforts have been directed towards the production and characterization of recombinant MMP-8 proteins to better understand its biological functions and to explore potential applications in drug development. The recombinant forms provide a controlled environment for studying MMP-8's enzymatic properties, substrate specificity, and interactions with inhibitors, paving the way for novel therapeutic strategies. Furthermore, understanding the role of MMP-8 in specific diseases may lead to the development of biomarkers for diagnosis or prognosis and may also inform treatment approaches that target MMP-8's activity to mitigate disease impact. Overall, the ongoing research surrounding MMP-8 underscores its importance in both basic biology and clinical applications, highlighting the need for continued exploration of its mechanisms and therapeutic potential.
