Analytical Data
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Gene name
SLC30A10
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简介
The SLC30A10 protein is a plasma membrane calcium:manganese antiporter that promotes the release of intracellular manganese and the simultaneous import of extracellular calcium. SLC30A10 Protein, Human (sf9, His, Strep, FLAG) is the recombinant human-derived SLC30A10 protein, expressed by sf9 insect cells , with N-Strep, C-Flag, N-8*His labeled tag.
- Application
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Alternative Names
SLC30A10; Zinc transporter 10; ZnT-10; Manganese transporter SLC30A10; Solute carrier family 30 member 10
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Species
Human
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Source
Baculovirus
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Tag
N-StrepⅡ;N-8*His;C-Flag
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6XR72
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Expression Region
G2-F485
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC30A10, a member of the solute carrier family, encodes a zinc transporter that plays a critical role in cellular zinc homeostasis. Mutations in this gene have been linked to various neurological and metabolic disorders, including hypozincemia and neurodegeneration, highlighting its importance in maintaining zinc levels within cells. Given the essential role of zinc in numerous biological processes such as enzyme function, DNA synthesis, and cell signaling, understanding the function of SLC30A10 is vital for elucidating the pathophysiological mechanisms of diseases associated with zinc imbalance. Research into the recombinant protein of SLC30A10 aims to unlock insights into its structure, function, and interaction with other cellular components, providing a potential avenue for therapeutic intervention. By analyzing this protein through techniques like crystallography and functional assays, scientists hope to design strategies to correct zinc transport deficiencies and mitigate disease symptoms, thus emphasizing the significance of SLC30A10 in both fundamental biology and clinical applications.
