Analytical Data
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基因名
Nucleolar transcription factor 1/UBTF
- Application
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别名
Autoantigen NOR-90 Upstream-binding factor 1 Short name:UBF-1 UBF
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P17480
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表达区间
1-670aa
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分子量
95.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Nucleolar transcription factor 1 (UBTF) is a critical protein involved in the regulation of ribosomal RNA (rRNA) transcription and ribosome biogenesis. As a high-mobility group (HMG) protein, UBTF binds to the core promoter of rRNA genes, facilitating the recruitment of RNA polymerase I and several transcriptional co-factors. Research on UBTF has garnered significant attention due to its essential role in coordinating cellular growth, proliferation, and response to stress, which are crucial for maintaining cellular homeostasis. Abnormalities in UBTF function have been linked to various diseases, including cancer, where dysregulated ribosome biogenesis often contributes to tumorigenesis. Additionally, UBTF is involved in other cellular processes, such as chromatin remodeling and apoptosis, further underscoring its importance in cell biology. Recent advancements in structural biology have enabled the characterization of UBTF's interaction with nucleolar components, offering insights into its multifaceted functions. Consequently, studies focusing on recombinant UBTF proteins aim to elucidate its mechanistic roles and regulatory pathways, paving the way for novel therapeutic strategies targeting diseases associated with ribosomal dysfunction and growth control. Understanding the precise molecular mechanisms by which UBTF operates may yield new avenues for intervention in pathologies where ribosome biogenesis is perturbed, ultimately enhancing our knowledge of cell growth regulation and cancer biology.
