Analytical Data
-
基因名
GGPS1
- Application
-
别名
(2E,6E)-farnesyl diphosphate synthaseDimethylallyltranstransferase (EC:2.5.1.1)Farnesyl diphosphate synthaseFarnesyltranstransferase (EC:2.5.1.29)Geranylgeranyl diphosphate synthaseGeranyltranstransferase (EC:2.5.1.10)
-
种属
Human
-
表达系统
E. coli
-
标签
N- His-SUMO
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
O95749
-
表达区间
1-300aa
-
分子量
50.9 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GGPS1 (Geranylgeranyl pyrophosphate synthase 1) is an essential enzyme involved in the biosynthesis of geranylgeranyl pyrophosphate, a critical lipid precursor for the post-translational modification of proteins, particularly small GTPase proteins. The significance of GGPS1 lies in its role in various cellular processes, including signal transduction, cell growth, and differentiation, highlighting its importance in maintaining cellular homeostasis. Dysregulation of GGPS1 has been linked to several diseases, such as cancer and cardiovascular disorders, making it a potential target for therapeutic intervention. Recent studies have focused on the recombinant expression of GGPS1 to better understand its enzymatic mechanisms and to explore its structure-function relationships. The generation of recombinant GGPS1 allows for in-depth biochemical analysis, facilitating the investigation of enzyme kinetics, substrate specificity, and potential inhibitors. Moreover, the availability of purified GGPS1 protein provides a valuable resource for structural biology studies, including X-ray crystallography and NMR spectroscopy, which can unveil the enzyme's three-dimensional structure and correlate it with its catalytic activity. Understanding the molecular basis of GGPS1 function can also contribute to the design of small molecules that modulate its activity, offering new avenues for drug discovery and development in related diseases. Overall, the research on recombinant GGPS1 is pivotal for elucidating its biological roles and developing novel therapeutic strategies targeting GGPS1-mediated pathways.
