Analytical Data
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Gene name
TRIP13
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简介
The TRIP13 protein plays a key role in meiosis, affecting chromosome reorganization and structural development. It is critical for the formation of crossing and noncrossing pathways, homologous synapses, and synaptonemal complexes. TRIP13 Protein, Human (His, Strep) is the recombinant human-derived TRIP13 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.
- Application
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Species
Human
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Source
E. coli
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Tag
N-StrepⅡ;N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15645
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Expression Region
M1-I432
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Protein Length
Full Length
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TRIP13, or thyroid receptor interactor 13, is a member of the AAA+ ATPase family and plays a crucial role in various cellular processes, including cell cycle regulation and DNA damage response. Recent studies have highlighted TRIP13's involvement in the regulation of the spindle assembly checkpoint, a critical mechanism ensuring proper chromosome segregation during mitosis. Abnormalities in TRIP13 expression and function have been linked to several cancers, particularly those associated with chromosomal instability. Researchers have focused on understanding the structural and functional aspects of TRIP13, revealing its role in the disassembly of protein complexes involved in mitotic checkpoints. Additionally, TRIP13's interactions with other proteins, including the mitotic regulator MAD2, suggest that it may serve as a potential therapeutic target for cancer treatment. Investigating TRIP13's biochemical functions and its impact on cell cycle dynamics offers promising avenues for both basic and translational research, with the potential to unlock new strategies for cancer intervention and to enhance our understanding of cellular homeostasis.
