Analytical Data
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Gene name
GGPS1
- Application
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Alternative Names
GGPPS1; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyltranstransferase; Geranylgeranyl diphosphate synthase; Geranyltranstransferase
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
O95749
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Expression Region
Met1~His290
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Molecular Weight
37kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GGPS1 (Geranylgeranyl pyrophosphate synthase 1) is an essential enzyme involved in the biosynthesis of geranylgeranyl pyrophosphate, a critical lipid precursor for the post-translational modification of proteins, particularly small GTPase proteins. The significance of GGPS1 lies in its role in various cellular processes, including signal transduction, cell growth, and differentiation, highlighting its importance in maintaining cellular homeostasis. Dysregulation of GGPS1 has been linked to several diseases, such as cancer and cardiovascular disorders, making it a potential target for therapeutic intervention. Recent studies have focused on the recombinant expression of GGPS1 to better understand its enzymatic mechanisms and to explore its structure-function relationships. The generation of recombinant GGPS1 allows for in-depth biochemical analysis, facilitating the investigation of enzyme kinetics, substrate specificity, and potential inhibitors. Moreover, the availability of purified GGPS1 protein provides a valuable resource for structural biology studies, including X-ray crystallography and NMR spectroscopy, which can unveil the enzyme's three-dimensional structure and correlate it with its catalytic activity. Understanding the molecular basis of GGPS1 function can also contribute to the design of small molecules that modulate its activity, offering new avenues for drug discovery and development in related diseases. Overall, the research on recombinant GGPS1 is pivotal for elucidating its biological roles and developing novel therapeutic strategies targeting GGPS1-mediated pathways.
