Analytical Data
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Gene name
KBTBD2
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简介
KBTBD2 in the BCR E3 ubiquitin ligase complex is a key regulator in the insulin signaling pathway and affects the insulin sensitivity of adipocytes. Its effects are manifested by regulating PIK3R1/p85alpha abundance by coordinating the ubiquitination process for PIK3R1 degradation. KBTBD2 Protein, Human (sf9) is the recombinant human-derived KBTBD2 protein, expressed by sf9 insect cells , with tag free.
- Application
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Alternative Names
KBTBD2; Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1
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Species
Human
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Source
Baculovirus
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IY47
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Expression Region
S2-V623
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KBTBD2, or Kelch repeat and BTB domain-containing protein 2, is a member of the BTB-Kelch protein family, known for its roles in protein-protein interactions and ubiquitination processes. Research on KBTBD2 has gained traction due to its involvement in critical biological functions such as cell cycle regulation, signal transduction, and stress responses. Aberrant expression of KBTBD2 has been linked to various diseases, including cancer and neurodegenerative disorders, underscoring its potential as a therapeutic target. Studies have indicated that KBTBD2 may regulate the stability and activity of key cellular proteins through ubiquitination, thereby influencing cellular homeostasis. The investigation of KBTBD2 recombinant proteins offers insights into its structure-function relationships and interaction mechanisms, vital for understanding its biological roles. Furthermore, generating recombinant KBTBD2 protein may facilitate the development of inhibitors or modulators that could serve as novel therapeutic agents in managing diseases associated with dysregulated KBTBD2 activity. This research is pivotal not only for comprehending the underlying molecular mechanisms of KBTBD2 but also for pioneering new strategies in disease intervention and treatment.
