Analytical Data
-
Gene name
PSMG3
-
简介
The PSMG3 protein acts as a chaperone and actively promotes the assembly of the 20S proteasome. It involves potential cooperation with the PSMG1-PSMG2 heterodimer to ensure precise assembly of the proteasome. PSMG3 Protein, Human is the recombinant human-derived PSMG3 protein, expressed by E. coli , with tag free.
- Application
-
Alternative Names
PSMG3; Proteasome assembly chaperone 3; PAC-3; hPAC3
-
Species
Human
-
Source
E. coli
-
Tag
Tag Free
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9BT73
-
Expression Region
M1-W122
-
Protein Length
Full Length
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PSMG3, or proteasome subunit gamma 3, is a vital component of the 26S proteasome, a multi-subunit complex responsible for the degradation of ubiquitinated proteins, playing a crucial role in maintaining cellular homeostasis. Research into PSMG3 has intensified due to its implications in various biological processes, including cell cycle regulation, apoptosis, and immune response. Dysregulation of the proteasome system has been linked to several diseases, including cancer and neurodegenerative disorders. Understanding the structure and function of PSMG3 is essential for elucidating its role in proteasomal function. Recent studies have employed advanced techniques such as X-ray crystallography and cryo-electron microscopy to explore the conformational dynamics of PSMG3, revealing insights into its interactions within the proteasome framework. Additionally, investigations into PSMG3's post-translational modifications are shedding light on its regulatory mechanisms. As the demand for targeted therapies grows, PSMG3 presents a potential therapeutic target, making its study increasingly pertinent in the context of drug development and disease treatment strategies. The ongoing research aims not only to delineate the molecular functions of PSMG3 but also to harness this knowledge for biomedical applications, underscoring its significance in the landscape of molecular biology and therapeutic innovation.
