Analytical Data
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Gene name
NOV/CCN3
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简介
NOV/CCN3 proteins are involved in a variety of biological processes, including migration, differentiation, survival, and inflammation. It acts by binding to integrins or membrane receptors such as NOTCH1. NOV/CCN3 Protein, Rhesus Macaque (sf9, His) is the recombinant Rhesus Macaque-derived NOV/CCN3 protein, expressed by Sf9 insect cells , with C-His labeled tag.
- Application
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Alternative Names
Nephroblastoma Overexpressed Gene Protein; IBP-9; CCN3; IGFBP9; NOVH
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Species
Rhesus Macaque
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Source
Baculovirus
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
F6WCM6
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Expression Region
T32-M357
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Protein Length
Full Length of Mature Protein
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The NOV/CCN3 protein, a member of the CCN family, plays significant roles in various biological processes, including cell proliferation, differentiation, and matrix formation. It is characterized by its unique modular structure, comprising multiple domains that facilitate interactions with specific receptors and other proteins. Research has indicated that NOV/CCN3 is involved in several pathological conditions, including fibrosis, cancer, and cardiovascular diseases, making it a target of interest for therapeutic interventions. Studies have shown that NOV/CCN3 can modulate signaling pathways such as those involving TGF-β and Wnt, influencing cellular behavior and tissue homeostasis. Due to its dual role in promoting both normal tissue repair and pathological remodeling, understanding the precise functions and mechanisms of NOV/CCN3 could provide insights into novel treatment strategies for diseases associated with aberrant cell signaling and tissue remodeling. Investigating recombinant forms of NOV/CCN3 allows researchers to dissect its biological effects in vitro and in vivo, guiding the development of targeted therapies that could mitigate its roles in disease progression while harnessing its beneficial properties in tissue regeneration. As advances in biotechnology continue to enhance our ability to produce and manipulate these recombinant proteins, the potential for NOV/CCN3 to serve as a biomarker and therapeutic target in clinical settings is becoming increasingly evident, underscoring the importance of ongoing research in this area.
