Analytical Data
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Gene name
REG4
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简介
The REG4 protein is a calcium-dependent lectin that functions as a pattern recognition receptor (PRR) in the innate immune system. REG4 has specific affinity for α-mannan on Candida albicans hyphae and triggers phosphorylation of the FCER1G immunoreceptor tyrosine activation motif (ITAM), thereby activating SYK, CARD9 and NF-kappa-B. REG4 Protein, Rat (HEK293, Fc) is the recombinant rat-derived REG4 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Regenerating islet-derived protein 4; GISP; RELP; REG4
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Species
Rat
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q68AX7
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Expression Region
D23-P157
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Protein Length
Full Length of Mature Protein
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Molecular Weight
49 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
REG4, a member of the regenerating family of proteins, has emerged as a significant biomarker and potential therapeutic target in various diseases, particularly in gastrointestinal disorders and certain cancers. Initially identified in the context of intestinal regeneration, REG4 is known to be upregulated in response to injury, inflammation, and tissue repair processes. This protein plays a crucial role in cell proliferation, differentiation, and survival, highlighting its importance in maintaining epithelial integrity. Recent studies have demonstrated that REG4 is overexpressed in conditions such as inflammatory bowel disease (IBD) and colorectal cancer, suggesting a potential link between REG4 levels and disease progression. Furthermore, its involvement in the regulation of immune responses and gut microbiota interactions underscores its relevance in maintaining gut homeostasis. Research into REG4 is expanding rapidly, focusing on its molecular mechanisms and potential as a diagnostic marker or therapeutic agent. Given its dual role in both regenerative processes and tumorigenesis, understanding REG4’s multifaceted functions could pave the way for novel strategies in managing gut-related diseases and improving patient outcomes. Thus, the ongoing investigation into REG4 not only provides insights into its biological significance but also holds promise for innovative therapeutic interventions in the realm of gastrointestinal health and oncology.
