Analytical Data
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基因名
gp130/IL6ST
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简介
Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family[1]. gp130 inhibits the cell growth and migration[3], decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity[4][5]. gp130/IL6ST Protein, Human (HEK293, Fc) is a recombinant protein with a Fc tag produced by HEK293 cells.
- Application
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别名
Interleukin-6 receptor subunit beta; IL-6RB; CDw130; gp130; CD130; IL6ST
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种属
Human
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P40189-1
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表达区间
E23-I618
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蛋白长度
Extracellular Domain
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分子量
97-130 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
gp130/IL6ST, known as glycoprotein 130, is a crucial signaling receptor component for the interleukin-6 (IL-6) cytokine family. This receptor plays a vital role in mediating immune responses, hematopoiesis, and inflammation. Abnormal signaling through gp130 has been implicated in various diseases, including autoimmune disorders and cancers, making it a significant target for therapeutic interventions. Researchers have been interested in the production of recombinant gp130/IL6ST proteins to study their structure, function, and potential as therapeutic agents. These recombinant proteins can help elucidate the mechanisms of IL-6 signaling pathways and facilitate the development of strategies to modulate these pathways in disease contexts. Additionally, gp130/IL6ST has applications in drug development, particularly in the design of monoclonal antibodies and other biologics aimed at blocking IL-6 signaling. By unraveling the intricate roles of gp130 in cellular communication, scientists aim to provide insights into potential biomarkers for disease prognosis and treatment responses, further highlighting the protein's importance in medical research.
