Analytical Data
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基因名
HIST1H2BM
- Application
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别名
H2B 291B
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种属
Mouse
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P10854
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表达区间
2-126aa
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分子量
17.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The HIST1H2BM gene encodes a variant of histone H2B, a core component of nucleosomes, which play a critical role in the structural organization of DNA within the cell nucleus. Histones are fundamental to the processes of gene regulation, DNA packaging, and chromatin remodeling, making them instrumental in various cellular functions, including transcription, replication, and repair. Recent studies have highlighted the significance of specific histone modifications in epigenetic regulation, influencing cellular differentiation and development. HIST1H2BM, specifically, has garnered attention due to its implications in various diseases, including cancer, where aberrations in histone gene expression can lead to dysregulation of gene activity and chromatin structure. Research on recombinant HIST1H2BM protein aims to elucidate its structural and functional properties, explore its interactions with other proteins, and assess its role in epigenetic modifications. By studying this histone variant, scientists hope to gain insights into the complex regulatory mechanisms underlying gene expression and chromatin dynamics, potentially leading to novel therapeutic approaches for diseases associated with epigenetic alterations. Additionally, understanding the biochemical pathways involving HIST1H2BM can provide a clearer picture of its contributions to cellular processes, further emphasizing the importance of histones in maintaining genomic integrity and regulating cellular homeostasis. This research area continues to expand as advanced techniques in molecular biology and biochemistry offer new avenues to investigate the multifaceted roles of histones in health and disease.
