Analytical Data
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基因名
Sorcin/SRI
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简介
The Sorcin/SRI protein is a calcium-binding regulator that complexly regulates excitation-contraction coupling in the heart and plays a critical role in maintaining calcium homeostasis within the sarcoplasmic reticulum. As a homodimer, Sorcin/SRI affects the activity of the RYR2 calcium channel, helping to precisely control calcium dynamics in cardiomyocytes. Sorcin/SRI Protein, Human (sf9, His-GST) is the recombinant human-derived Sorcin/SRI protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Application
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别名
22 kDa protein; CP22; V19
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种属
Human
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表达系统
Baculovirus
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标签
N-His;N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P30626
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表达区间
M1-V198
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蛋白长度
Full Length
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分子量
47 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Sorcin (soluble resistance-related calcium-binding protein) is a member of the penta-EF-hand family of calcium-binding proteins, primarily known for its role in cellular calcium homeostasis and its involvement in various physiological processes, including apoptosis, cytoskeletal dynamics, and signal transduction. Recent studies have highlighted its significant role in cancer biology, as elevated levels of Sorcin have been associated with chemoresistance and poor prognosis in various cancers. The study of Sorcin/SRI (Sorcin-related protein) recombinant proteins is crucial for unraveling the underlying molecular mechanisms of its functions and interactions in cellular pathways. By producing recombinant Sorcin through molecular cloning techniques and subsequent expression in suitable host systems, researchers can investigate its calcium-binding properties, structural dynamics, and influence on cancer cell behavior. The ability to manipulate and analyze Sorcin's interactions with other cellular proteins also provides valuable insights into potential therapeutic targets for overcoming drug resistance in cancer treatment. Thus, research on Sorcin/SRI recombinant proteins not only contributes to our understanding of fundamental biological processes but also holds promise for developing innovative strategies to enhance the efficacy of existing cancer therapies.
