Analytical Data
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Gene name
Statherin
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简介
Statherin, a salivary protein, crucially regulates saliva's calcium salt supersaturation by inhibiting calcium phosphate salt precipitation. Beyond preventing crystallization, statherin significantly influences hydroxyapatite crystal formation on teeth, highlighting its dual role in dental health. It prevents undesirable mineral deposition and impacts tooth mineralization dynamics. Statherin Protein, Human (HEK293, Fc) is the recombinant human-derived Statherin protein, expressed by HEK293 , with C-mFc labeled tag.
- Application
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Alternative Names
Statherin; STATH
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Species
Human
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Source
HEK293
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Tag
C-mFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P02808-1
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Expression Region
M1-F62
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Protein Length
Full Length of Isoform-1
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Molecular Weight
36 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Statherin is a 43-amino-acid peptide originally identified in human saliva, playing a crucial role in oral biology and dental health. Its primary function is to inhibit calcium phosphate precipitation, thereby regulating calcium levels in saliva and contributing to the maintenance of tooth enamel. Researchers became increasingly interested in statherin due to its potential applications in therapeutic and preventive dentistry, particularly in the context of dental caries and periodontal diseases. Recent studies have focused on the recombinant production of statherin, utilizing methods such as recombinant DNA technology to produce active forms of the peptide for more controlled and concentrated studies. This approach enables the exploration of statherin's biochemical properties, interaction with hydroxyapatite (the main mineral component of tooth enamel), and its ability to mediate biomineralization processes. Understanding statherin's function at a molecular level could lead to novel strategies for dental care products, enhancing remineralization of demineralized enamel and potentially leading to innovative approaches in oral health management. As such, statherin serves as a promising candidate for further exploration in the context of preventive dental therapies, offering insights into how naturally occurring biomolecules can be harnessed for improved oral health outcomes.
