Analytical Data
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基因名
VNN1/Vanin-1
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简介
Vanin-1 (VNN1) is an amide hydrolase that specifically hydrolyzes one carbon amide bond in D-panthionine.The function of this enzyme is essential for recycling pantothenic acid (vitamin B5) and releasing cysteamine.VNN1/Vanin-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived VNN1/Vanin-1 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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别名
Pantetheinase; Pantetheine hydrolase; Vascular non-inflammatory molecule 1; Vanin-1
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种属
Mouse
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Z0K8
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表达区间
M1-S487
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蛋白长度
Partial
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分子量
85-90 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VNN1, also known as Vanin-1, is a member of the Vanin family of proteins and is primarily expressed in various tissues, including the kidney, liver, and intestine. It serves a crucial role in the metabolism of the antioxidant glutathione and is involved in the modulation of immune responses as well as inflammatory processes. Research has indicated that VNN1 plays a significant role in the regulation of oxidative stress, with implications for various pathological conditions, including cardiovascular diseases, cancer, and neurodegenerative disorders. Given its pivotal functions, there is increasing interest in recombinant VNN1 protein as a therapeutic target. Studies focus on its structure, enzymatic activity, and potential interactions with other cellular mechanisms. Understanding the molecular characteristics and biological functions of VNN1 can facilitate the development of novel strategies for disease intervention, particularly in conditions characterized by oxidative imbalance. Furthermore, recombinant VNN1 protein offers opportunities for exploring its application in drug development and therapeutic interventions, enabling researchers to investigate how modulating its activity could benefit patient outcomes in diseases where oxidative stress is a contributing factor. Thus, the ongoing exploration of VNN1/Vanin-1 serves as a promising avenue for advancing biomedical research and enhancing our comprehension of its multifaceted roles in health and disease.
