Analytical Data
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基因名
UMP-CMP kinase/CMPK1
- Application
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别名
Deoxycytidylate kinaseUniRule annotation Short name: CKUniRule annotation Short name: dCMP kinaseUniRule annotation Nucleoside-diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation) Uridine monophosphate/cytidine monophosphate kinaseUniRule annotation Short name: UMP/CMP kinaseUniRule annotation Short name: UMP/CMPK
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种属
Mouse
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9DBP5
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表达区间
1-196aa
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分子量
38.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UMP-CMP kinase (CMPK1) is a pivotal enzyme involved in nucleotide metabolism, specifically in the phosphorylation of UMP and CMP to their respective diphosphate forms, UTP and CMP. This activity is crucial for the synthesis of RNA and DNA, making CMPK1 a significant player in cellular proliferation and metabolism. The enzyme has garnered attention due to its potential implications in various pathological conditions, including cancer and viral infections, where nucleotide metabolism is often dysregulated. The study of CMPK1 is further amplified by the need for robust biochemical tools to better understand its role and regulation. Recombinant CMPK1 proteins allow for detailed characterization of the enzyme’s kinetics, substrate specificity, and interactions with other cellular components. Additionally, the availability of pure and active CMPK1 is essential for potential therapeutic applications targeting nucleotide metabolism. Research has demonstrated that manipulating CMPK1 activity can influence cellular responses to different stimuli, providing insights into its regulatory mechanisms. Thus, the development and study of recombinant CMPK1 not only facilitate a deeper understanding of nucleotide metabolism but also hold promise for innovative therapeutic strategies against diseases linked to nucleotide dysregulation.
