Analytical Data
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Gene name
CKMT2
- Application
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Alternative Names
(Basic-type mitochondrial creatine kinase)(Mib-CK)(Sarcomeric mitochondrial creatine kinase)(S-MtCK)
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Species
Mouse
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Source
Yeast
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6P8J7
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Expression Region
40-419aa
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Molecular Weight
45.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CKMT2, or creatine kinase mitochondrial 2, is a nuclear-encoded enzyme primarily located in the mitochondria, playing a crucial role in cellular energy metabolism. It catalyzes the conversion of creatine and adenosine triphosphate (ATP) to phosphocreatine and adenosine diphosphate (ADP), thereby facilitating the rapid regeneration of ATP in tissues with high energy demands, such as heart and skeletal muscle. Recent studies have highlighted the significance of CKMT2 in metabolic diseases and mitochondrial dysfunction, suggesting its potential involvement in conditions such as heart failure, neurodegenerative disorders, and muscle wasting. The recombinant expression of CKMT2 allows researchers to investigate its structural and functional properties in detail, enabling a better understanding of its role in energy homeostasis and its implications in disease processes. Furthermore, studying CKMT2 through recombinant protein techniques may pave the way for therapeutic approaches aimed at restoring its function in pathological conditions, contributing to novel strategies in metabolic disease management. Overall, the research on CKMT2 is poised to reveal critical insights into mitochondrial health and energy regulation, underscoring its potential as a biomarker or therapeutic target in various metabolic disorders.
