Analytical Data
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基因名
CKMT2
- Application
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别名
MtCK; CK-MT2; SMTCK; Mib-CK; Creatine Kinase S-type; Basic-type mitochondrial creatine kinase; Sarcomeric mitochondrial creatine kinase
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P17540
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表达区间
Glu40~Lys419
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分子量
47.0kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CKMT2, or creatine kinase mitochondrial 2, is a nuclear-encoded enzyme primarily located in the mitochondria, playing a crucial role in cellular energy metabolism. It catalyzes the conversion of creatine and adenosine triphosphate (ATP) to phosphocreatine and adenosine diphosphate (ADP), thereby facilitating the rapid regeneration of ATP in tissues with high energy demands, such as heart and skeletal muscle. Recent studies have highlighted the significance of CKMT2 in metabolic diseases and mitochondrial dysfunction, suggesting its potential involvement in conditions such as heart failure, neurodegenerative disorders, and muscle wasting. The recombinant expression of CKMT2 allows researchers to investigate its structural and functional properties in detail, enabling a better understanding of its role in energy homeostasis and its implications in disease processes. Furthermore, studying CKMT2 through recombinant protein techniques may pave the way for therapeutic approaches aimed at restoring its function in pathological conditions, contributing to novel strategies in metabolic disease management. Overall, the research on CKMT2 is poised to reveal critical insights into mitochondrial health and energy regulation, underscoring its potential as a biomarker or therapeutic target in various metabolic disorders.
