Analytical Data
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基因名
ZBP1
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简介
ZBP1 is an important innate sensor that defends against viruses by recognizing Z-RNA structures and inducing PANoptosis. It binds Z-RNA through TNF-α family members and stimulates RIPK3 and MLKL to activate necroptosis. ZBP1 Protein, Human (His) is the recombinant human-derived ZBP1 protein, expressed by E. coli , with C-6*His labeled tag.
- Application
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别名
Z-DNA-Binding Protein 1; Tumor Stroma and Activated Macrophage Protein DLM; ZBP1; C20orf183; DLM1
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种属
Human
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表达系统
E. coli
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H171-1
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表达区间
M1-S149
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蛋白长度
Partial
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分子量
20 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZBP1, also known as Z-DNA binding protein 1, plays a critical role in the immune response to viral infections and cellular stress. As a DNA-binding protein, ZBP1 can recognize Z-form DNA, which is formed during specific cellular conditions, such as viral replication. The protein is integral to the detection of cytosolic DNA, acting as a sensor that triggers signaling pathways leading to the activation of innate immune responses. Research indicates that ZBP1 mediates inflammatory responses and regulates cell death pathways, such as pyroptosis, in the context of infection. This has prompted interest in the development of ZBP1 recombinant proteins for potential therapeutic applications, including vaccines and targeted treatments for viral diseases and cancer modalities. Understanding the structure and function of ZBP1 at a molecular level can elucidate its role in immune regulation and provide insights into therapeutic interventions. In addition, recombination technologies allow for the production of ZBP1 in various expression systems, facilitating extensive studies on its regulatory mechanisms and interactions with other cellular factors. As such, ZBP1 has emerged as a significant focus in immunology and molecular biology, with promising implications for advancing antiviral strategies and enhancing therapeutic efficacy.
