Analytical Data
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Gene name
ZBP1
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简介
ZBP1 is an important innate sensor that defends against viruses by recognizing Z-RNA structures and inducing PANoptosis. It binds Z-RNA through TNF-α family members and stimulates RIPK3 and MLKL to activate necroptosis. ZBP1 Protein, Human (His) is the recombinant human-derived ZBP1 protein, expressed by E. coli , with C-6*His labeled tag.
- Application
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Alternative Names
Z-DNA-Binding Protein 1; Tumor Stroma and Activated Macrophage Protein DLM; ZBP1; C20orf183; DLM1
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Species
Human
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Source
E. coli
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H171-1
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Expression Region
M1-S149
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Protein Length
Partial
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Molecular Weight
20 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZBP1, also known as Z-DNA binding protein 1, plays a critical role in the immune response to viral infections and cellular stress. As a DNA-binding protein, ZBP1 can recognize Z-form DNA, which is formed during specific cellular conditions, such as viral replication. The protein is integral to the detection of cytosolic DNA, acting as a sensor that triggers signaling pathways leading to the activation of innate immune responses. Research indicates that ZBP1 mediates inflammatory responses and regulates cell death pathways, such as pyroptosis, in the context of infection. This has prompted interest in the development of ZBP1 recombinant proteins for potential therapeutic applications, including vaccines and targeted treatments for viral diseases and cancer modalities. Understanding the structure and function of ZBP1 at a molecular level can elucidate its role in immune regulation and provide insights into therapeutic interventions. In addition, recombination technologies allow for the production of ZBP1 in various expression systems, facilitating extensive studies on its regulatory mechanisms and interactions with other cellular factors. As such, ZBP1 has emerged as a significant focus in immunology and molecular biology, with promising implications for advancing antiviral strategies and enhancing therapeutic efficacy.
