Analytical Data
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Gene name
RGM-C
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简介
RGM-C Protein, a BMP coreceptor, crucially modulates BMP signaling and regulates hepcidin (HAMP) expression, impacting iron homeostasis. It interacts with BMP2, BMP4, BMP6, BMPR1B, and TMPRSS6, forming a molecular network that collectively mediates BMP-related signaling pathways and iron regulation. RGM-C Protein, Human (HEK293, mFc) is the recombinant human-derived RGM-C protein, expressed by HEK293, with C-mFc labeled tag.
- Application
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Alternative Names
Hemojuvelin; Rgmc; DL-M; HFE2; HFE2AMGC23953; HJV; JH; RGMC; RGM-C
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Species
Human
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Source
HEK293
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Tag
C-mFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6ZVN8-1
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Expression Region
Q36-P145
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Protein Length
Partial
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Molecular Weight
45-55 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RGM-C (Repulsive Guidance Molecule C) is a member of the RGM family of proteins, known for its roles in neural development and axonal guidance. Recent studies have highlighted its involvement in various biological processes, including cell differentiation, organ development, and immune responses. Additionally, RGM-C has been recognized for its function in regulating iron metabolism through its interaction with the hemojuvelin (HJV) pathway, influencing hepcidin production and systemic iron homeostasis. Dysregulation of RGM-C has been implicated in several diseases, including neurodegenerative disorders and iron-related pathologies, making it a promising candidate for therapeutic interventions. Research on RGM-C primarily focuses on understanding its molecular mechanisms, interactions with other proteins, and potential applications in disease modeling and drug development. The exploration of RGM-C as a therapeutic target aims to provide insights into new strategies for modulating neural repair and iron metabolism-related conditions, paving the way for innovative treatment options. Understanding its structure-function relationship through the study of recombinant RGM-C proteins could unveil crucial information that impacts both basic biology and clinical applications, solidifying its importance in contemporary biomedical research.
