Analytical Data
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基因名
GRK5
- Application
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别名
GPRK5
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种属
Human
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表达系统
Baculovirus
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标签
N-His;N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P34947
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表达区间
E2-S590
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蛋白长度
Partial
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分子量
95.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
G protein-coupled receptor kinase 5 (GRK5) is a pivotal enzyme that plays a crucial role in the regulation of G protein-coupled receptors (GPCRs), which are essential for various physiological processes. Dysregulation of GRK5 is implicated in several diseases, including heart failure, neurodegenerative disorders, and certain cancers. The recombinant expression of GRK5 allows for the study of its functional properties, regulatory mechanisms, and interactions with other cellular proteins. Understanding GRK5's structure and function can provide insights into drug development targeting GPCR signaling pathways. Furthermore, studies involving the recombinant form of GRK5 can aid in exploring potential therapeutic strategies aimed at modulating its activity. The production of GRK5 as a recombinant protein also facilitates the characterization of its enzymatic activity and the identification of novel inhibitors, which could have significant implications for treating diseases associated with GPCR dysregulation. Overall, the investigation of GRK5 through recombinant technologies holds promise for advancing our understanding of its biological significance and therapeutic potential.
