Analytical Data
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Gene name
GRK5
- Application
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Alternative Names
GPRK5
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Species
Human
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Source
Baculovirus
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Tag
N-His;N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P34947
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Expression Region
E2-S590
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Protein Length
Partial
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Molecular Weight
95.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
G protein-coupled receptor kinase 5 (GRK5) is a pivotal enzyme that plays a crucial role in the regulation of G protein-coupled receptors (GPCRs), which are essential for various physiological processes. Dysregulation of GRK5 is implicated in several diseases, including heart failure, neurodegenerative disorders, and certain cancers. The recombinant expression of GRK5 allows for the study of its functional properties, regulatory mechanisms, and interactions with other cellular proteins. Understanding GRK5's structure and function can provide insights into drug development targeting GPCR signaling pathways. Furthermore, studies involving the recombinant form of GRK5 can aid in exploring potential therapeutic strategies aimed at modulating its activity. The production of GRK5 as a recombinant protein also facilitates the characterization of its enzymatic activity and the identification of novel inhibitors, which could have significant implications for treating diseases associated with GPCR dysregulation. Overall, the investigation of GRK5 through recombinant technologies holds promise for advancing our understanding of its biological significance and therapeutic potential.
