Analytical Data
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Gene name
USP10
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简介
USP10 is a multifunctional hydrolase that plays a critical regulatory role in a variety of cellular processes. It stabilizes the tumor suppressor p53/TP53 by deubiquitinating the tumor suppressor p53/TP53 in the cytoplasm, thereby counteracting MDM2-mediated degradation. USP10 Protein, Human (sf9) is the recombinant human-derived USP10 protein, expressed by sf9 insect cells , with tag free.
- Application
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Alternative Names
USP10; Ubiquitin carboxyl-terminal hydrolase 10; Deubiquitinating enzyme 10; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10
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Species
Human
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Source
Baculovirus
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14694
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Expression Region
A2-L798
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Protein Length
Full Length of Mature Protein
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
USP10, a member of the ubiquitin-specific protease family, plays a critical role in regulating protein degradation and cellular signaling pathways through deubiquitination processes. Studies have shown that USP10 is involved in various biological processes, including the modulation of p53 activity, influencing cell cycle progression, and regulating immune responses. Given its pivotal role in controlling ubiquitin signaling, USP10 has garnered attention in cancer research, as altered expression levels are often correlated with tumor progression and poor prognosis in several cancer types. Additionally, USP10 has been implicated in the response to viral infections, suggesting its potential as a therapeutic target in antiviral strategies. Understanding the structure and function of USP10, particularly through the study of recombinant protein expressed in suitable systems, is vital for elucidating its mechanisms and therapeutic potential. Researchers are now focusing on characterizing USP10 to explore its interactions with substrates and its involvement in disease pathways, further emphasizing its importance in both basic biology and potential clinical applications.
