Cat: IPD-X24639

Recombinant Mouse Alpha-crystallin A chain/CRYAA Protein,His

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Analytical Data

  • 基因名

    Alpha-crystallin A chain/CRYAA

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    CRY-AA; CRYA-A; CRYA1; HSPB4; Heat shock protein beta-4

  • 种属

    Mouse

  • 表达系统

    E. coli

  • 标签

    N-His

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P24622

  • 表达区间

    Asp2~Ser173

  • 分子量

    21kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

Alpha-crystallin A chain (CRYAA) is a crucial component of the eye lens, playing a vital role in maintaining lens transparency and preventing protein aggregation, which is essential for proper vision. CRYAA belongs to the small heat shock protein family, exhibiting chaperone-like properties that help protect cellular proteins from stress-induced damage. Research on the recombinant form of CRYAA has gained significance due to its potential therapeutic applications in ocular diseases, particularly cataract formation, which remains a leading cause of blindness globally. The ability to produce recombinant CRYAA allows for detailed structural and functional studies, enabling scientists to understand its protective mechanisms at a molecular level. Furthermore, studies have indicated that CRYAA might have implications beyond the lens, influencing cellular stress responses and playing a role in various pathological conditions, including neurodegenerative diseases. The exploration of CRYAA's functions through recombinant protein allows for innovative approaches to drug development and the design of novel therapies aimed at enhancing visual health and overall protein homeostasis. This research highlights the importance of CRYAA as a multi-functional protein, bridging gaps between basic and clinical science, ultimately paving the way for advancements in treatments for eye disorders and age-related conditions, thus improving patient outcomes.

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Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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